A new oxidatively stable ligand for the chiral functionalization of amino acids in Ni(II)–Schiff base complexes

• Alena V. Dmitrieva,
• Oleg A. Levitskiy,
• Yuri K. Grishin and
• Tatiana V. Magdesieva

Beilstein J. Org. Chem. 2023, 19, 566–574, doi:10.3762/bjoc.19.41

• complex. Solubility of the t-Bu-containing ligand and its Schiff base complexes is increased, facilitating scaling-up the reaction procedure and isolation of the functionalized amino acid. Keywords: asymmetric synthesis; chiral auxiliaries; cysteine derivatives; Ni–Schiff base complexes; voltammetry

• testing; Introduction Asymmetric synthesis of functionalized amino acids is a subject of intense research because these compounds are of great demand for pharmaceutical industry, health care, and food production [1][2][3]. Various approaches to enantiomerically enriched amino acids have been developed

Reductive opening of a cyclopropane ring in the Ni(II) coordination environment: a route to functionalized dehydroalanine and cysteine derivatives

• Oleg A. Levitskiy,
• Olga I. Aglamazova,
• Yuri K. Grishin and
• Tatiana V. Magdesieva

Beilstein J. Org. Chem. 2022, 18, 1166–1176, doi:10.3762/bjoc.18.121

• base complexes of (S)-N-(N-benzylprolyl)aminobenzophenone and ʟ-amino acids (i.e., (R)-cysteine derivatives) [48]. Conclusion Electroreductive opening of a cyclopropane ring in α,α-cyclopropanated amino acids in the form of Ni(II)–Schiff base complexes was studied. Preliminary voltammetry testing